The SPINTEC and SyMMES labs offer a 24 months post-doctoral position, starting in early 2018, on the design of magnetically actuated nanoparticles (NPs) for targeted cancer therapy. This work is part of the Nanoviber EuroNanomed2 project, with the general goal of achieving preclinical validation and toxicology assessment of these particles.
Based on previous results obtained in our lab, the candidate will conduct the following studies:
1) Particles fabrication based on top-down and bottom-up approaches were developed in our laboratory to prepare biocompatible magnetic particles suitable for the foreseen application.
2) Particles functionalization to provide versatile chemical functionalities for easy grafting of biomolecules onto their surfaces.
3) Toxicology and in vitro efficiency : Cancer cells death will be assessed after NPs incubation and exposure to magnetic field. Particles toxicity and cells response will be assessed using classical toxicology assays.
These studies will allow the optimization of the treatment protocol (particles fabrication and optimization; magnetic field frequency, amplitude, duration, etc.) to be used for the forthcoming preclinical validation.
Required qualification is a multi-disciplinary PhD degree in biomedical sciences, biology, nanoscience or nanotechnology. Ability to conduct animal experimentation would be an asset. Applications with detailed CV, letter of motivation and contact information for two references should be sent by email to robert.morel@cea.fr.